HE4—a biomarker and target in renal fibrosis

klotho and renal fibrosis

CD248/Endosialin: A Novel Pericyte Target in Renal Fibrosis.

pericyte to myofibroblast transition and CKD. CD248 was first identified as a tumor vascular endothelial antigen in the early 1990s [8] ; however, it was later reported to be a marker of stromal fibroblasts and a subset of pericytes associated with tumor vessels as well as human mesenchymal stem cells, but not tumor endothelium [9, 10] . CD248 is known to bind to extracellular matrix proteins a...

Proteomic identification of cyclophilin A as a potential biomarker and therapeutic target in oral submucous fibrosis

Oral submucous fibrosis (OSF) is a pre-cancerous lesion, which is characterized by fibrosis of the oral submucosa. Despite large body of studies focusing on this disease, the molecular mechanisms underlying the progression of OSF remained unclear. In this study, 2-DE-based proteomic approaches were employed to identify the differently expressed proteins between OSF and normal tissues. In total,...

Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease

Progressive renal fibrosis in chronic kidney disease (CKD) greatly contributes to end-stage renal failure and is associated with high mortality. The identification of renal fibrosis biomarkers for the diagnosis and the monitoring of disease progression in CKD is urgently needed. Whole-transcriptomic analysis of renal tissues in a unilateral ureteral obstruction (UUO) mouse model revealed that t...

Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside?

Over the past two decades, the concept of the epithelial to mesenchymal transition (EMT) has been imported from embryology and oncology to fibrosis, particularly in the kidney. This interest in EMT in the context of renal fibrosis stems from observations of epithelial cells undergoing phenotypic changes reminiscent of fibroblasts. Whether EMT is actually a source of interstitial fibroblasts has...